Updating Our Microbiome Software and Hardware

Good bacteria, those living in symbiosis with us, are nourished by fruits, vegetables, specks, and nuts, whereas bad bacteria, those in dysbiosis with us and maybe contributing to disease, are fed by flesh, junk food and fast food, seafood, dairy, and eggs, as “youre seeing” at 0:12 in my video Microbiome: We Are What They Dine. Typical Western foods can “decimate” our very best nerve flora.

We live with trillions of symbionts, good bacteria that live in symbiosis with us. We assisted them, and they help us. A month on a plant-based diet upshots in an increase in the population of the good guys and a drop in the bad, the so-called pathobionts, the disease-causing imperfections. “Given the fade-out of pathobionts from the entrail, one would expect to observe a reduction in intestinal irritation in subjects.” So, researchers evaluated stool absorptions of lipocalin-2, “which is a sensitive biomarker of intestinal inflammation.” As you can see at 1:13 in my video, within a month of eating healthfully, it had “declined significantly…suggesting that aimed at promoting microbial homeostasis”–or balance–“by an SVD[ strict vegetarian food] resulted in reduced intestinal inflammation.” What’s more, this rebalancing may have played a role “in improved metabolic and immunological constants, ” that is, in immune organization parameters.

In contrast, on an “animal-based diet, ” you get increment of disease-associated genus like Bilophila wadsworthia, associated with inflammatory bowel disease, and Alistipes putredinis, found in abscesses and appendicitis, and a decrease in fiber-eating bacteria. When we feed fiber, the fiber-munching bacteria multiply, and we get more anti-inflammatory, anti-cancer short-chain fatty acids. When we snack less fiber, our fiber-eating bacteria starve away.

They are what we eat.

Eat a good deal of phytates, and our bowel botany come really good at breaking down phytates. We accepted this was just because we were naturally adopting for those populations of bacteria able to do that, but it turns out our nutrition can educate old imperfections new subterfuges. There’s one type of fiber in nori seaweed that our bowel bacteria can’t usually breakdown, but the bacteria in the ocean that eat seaweed have the enzyme to do so. When it was discovered that that enzyme was present in the guts of Japanese parties, it presented a mystery. Sure, sushi is gobbled raw, so some seaweed bacteria may have became it to their colons, but how could some naval bacteria thrive in the human gut? It didn’t need to. It transmitted the nori-eating enzyme to our own bowel bacteria.

“Consequently, the consumption of food with associated environmental bacteria is the most likely mechanism that promoted this CAZyme[ enzyme] update into the human nerve microbe”–almost like a software update. We have the same hardware, the same gut bacteria, but the bacteria precisely modernized their software to enable them to chew on something new.

Hardware can change, very. A study designation “The way to a man’s heart is through his intestine microbiota” was so called because the researchers were talking about TMAO, trimethylamine N-oxide. As you can see at 3:33 in my video, certain intestine vegetation can take carnitine from the maroon meat we gobble or the choline concentrated in dairy, seafood, and eggs, and alter it into a toxic compound, which may lead to an increase in our danger of heart attack, blow, and death.

This explains why those feeing more plant-based diets have lower blood absorptions of TMAO. However, they likewise display lower levels of the poison even though they are feed them a steak. You don’t encounter the same “conversion of dietary L-carnitine to TMAO…suggesting an adoptive response of the nerve microbiota in omnivores.” They are what we feed them.

As you can see at 4:17 in my video, if you give people cyclamate, a synthetic artificial sweetener, most of their bacteria don’t know what to do with it. But, if you feed it to people for ten days and adopt for the few bacteria that were hip to the new synthetic compound, eventually three districts of the cyclamate depleted is metabolized by the bacteria into another new deepen announced cyclohexylamine. Stop eating it, however, and those bacteria die back. Unfortunately, cyclohexylamine may be toxic and so was banned by the FDA in 1969. In a vintage Kool-Aid ad from 1969, Pre-Sweetened Kool-Aid was taken “off your grocer’s shelves, ” but Regular Kool-Aid “has no cyclamates” and “is completely safe for your part family.”

But, if you simply ate cyclamate now and then, it wouldn’t turn into cyclohexylamine because you wouldn’t have fed and fostered the gut flora specialized to do so. The same thing happens with TMAO. Those who really ingest red flesh, eggs, or seafood now and then would apparently fix very little of the toxin because they hadn’t been cultivating the bacteria that cause it.

Here’s the link to my video on TMAO: Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection. For an update on TMAO, attend How Our Gut Bacteria Can Use Eggs to Accelerate Cancer,Egg Industry Response to Choline and TMAO, and How to Reduce Your TMAO Levels.

Interested in more on stopping our gut bugs happy? See 😛 TAGEND

Microbiome: The Inside Story Prebiotics: Tending Our Inner Garden How to Change Your Enterotype Paleopoo: What We Can Learn from Fossilized Feces Gut Dysbiosis: Starving Our Microbial Self How to Develop a Healthy Gut Ecosystem How to Become a Fecal Transplant Super Donor The Role of the Gut Microbiome in Autism Gut Microbiome- Strike It Rich with Whole Grain Flashback Friday: Effect of Sucralose( Splenda) on the Microbiome Flashback Friday: What’s Your Gut Microbiome Enterotype ?

In health,

Michael Greger, M.D.

PS: If you haven’t more, you can subscribe to my free videos here and watch my live performances 😛 TAGEND

2019: Evidence-Based Weight Loss 2016: How Not To Die: The Role of Diet in Preventing, Arresting, and Reversing Our Top 15 Killers 2015: Food as Medicine: Preventing and Treating the Most Dreaded Diseases with Diet 2014: From Table to Able: Combating Disabling Diseases with Food 2013: More Than an Apple a Day 2012: Uprooting the Leading Causes of Death

Read more: nutritionfacts.org